The main thing to do differently is to not take a trailer on that road. We have done it four times and only taken the trailer once. The other three trips we did a combination of tent camping and staying in commercial lodging.
The road can be extremely washboarded which is hell on a little single-axle trailer on rubber suspension. The extreme bouncing scrambled everything in the trailer and we also had to get a break in the frame welded when we got back to Fairbanks. We got a lot of dings in the
fiberglass from flying gravel. Some of it from our own wheels. (Bill, we got mud flaps right after this trip.) Lots of semi-trucks blasting by throwing rocks and mud.
We were only willing to abuse the trailer like this because we bought it used and cheap and it was already beat up. I think the previous owners had been on this road or others just like it.
We saw no other travel trailers on these trips. What we did see were truck campers and a few small, sturdy class C and class B motorhomes. And these were also people who were willing to put up with some rock dings and mud.
Some highlights:
We saw caribou, grizzly, moose, black bears, and Dall sheep.
We celebrated the Solstice around an all-night campfire with some research biologists we met at a pull-out known as Happy Camp. The sun circled around and never went below the horizon.