I would guess it is, but best to have someone who has one answer this question. I know that an Escape
5th wheel would work with our 5.5 bed in our 2013 F150.
The best tow option the F150 offers is the 3.5L V-6 "Ecoboost." it's turbocharged, and even our big 4 door gets 17-22. I've yet to see the 22, but have seen 20 and better. Have not towed much with it as of yet. It has a tow capacity of 9200#s with a 3.31 rear gear.
We love it.