Welcome! My grandfather was a cigar smoker, and he lived to be 90 years old. In the end a car got him when he stepped off a curb with his hearing aid turned off. You can make of that what you want!
IMO a trailer is often more practical for full-timing. When you’ve got 365 days a year to explore, it doesn’t make sense to drive to a new place every day. A trailer allows you to unhitch and explore a region for several days or a month without packing up everything in the RV. A bit more space might be nice during an extended spell of bad weather, too.
Of course, if you’ll be boondocking
or stealth camping, you may want the all-in one mobility of the slide-in.